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Circulating microRNAs as potential biomarkers for smoking-related interstitial fibrosis.
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| Author |
Yuchuan Huang,Ya Dai,Jie Zhang,Changguo Wang,Dongliang Li,Jingqiu Cheng,Yanrong Lu,Kuoyan Ma,Lanlan Tan,Fang Xue,Bo Qin |
| Citation Information |
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 17: (2012) |
| Related Products |
MPXMCYTO-70K |
| Pub Med ID |
22512273 |
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Abstract
Numerous efforts have been made to indentify reliable and predictive biomarkers to detect the early signs of smoking-induced lung disease. Using 6-month cigarette smoking in mice, we have established smoking-related interstitial fibrosis (SRIF). Microarray analyses and cytokine/chemokine biomarker measurements were made to select circulating microRNAs (miRNAs) biomarkers. We have demonstrated that specific miRNAs species (miR-125b-5p, miR-128, miR-30e, and miR-20b) were significantly changed, both in the lung tissue and in plasma, and exhibited mainstream (MS) exposure duration-dependent pathological changes in the lung. These findings suggested a potential use of specific circulating miRNAs as sensitive and informative biomarkers for smoking-induced lung disease.
