Stem Cell Antibodies
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Stem Cell Antibody Brochures
Explore our most recent stem cell antibody brochures today and learn about the existing and new stem cell antibodies EMD Millipore has to offer.
Stem cells have the unique ability to turn into different tissues of the body based on specific environmental cues exerted upon the cells. The identification of the key proteins involved in maintaining stem cell identity and functional have been critical to understand stem cell biology. Key transcription factors such as Oct-4, Nanog and Sox-2 are critical in maintaining embryonic and induced pluripotent stem cells in their pluripotent state. Upon differentiation, many of these pluripotency genes are downregualted while other differentiated markers are upregulated depending on the local environmental cues. Understanding what causes these changes is the key to understanding stem cell biology.
EMD Millipore is committed to providing validated stem cell antibodies for common and novel protein targets which are related to all areas of stem cell biology. From pluripotent stem cells to neural and mesenchymal stem cells, antibodies exist in various formats for each target, validated in different research applications and cited in many publications.
Primary Stem Cell Antibodies
Anti-Podocalyxin-like protein I (Cytotoxic) Antibody, clone mAb 84
Future therapeutic applications of differentiated human embryonic stem cells (hESC) carry a risk of teratoma formation by contaminating undifferentiated hESC. EMD Millipore is introducing a series of novel monoclonal antibodies (mAbs) against surface antigens of undifferentiated hESC, showing strong reactivity against undifferentiated, but not differentiated hESC. These novel antibodies do not cross react with mouse fibroblasts and showed weak to no reactivity against human embryonal carcinoma cells.
Notably, anti-Podocalyxin-like protein-1, clone mAb 84 is cytotoxic to undifferentiated hESC and NCCIT cells in a concentration-dependent, complement-independent manner.
Stem Cell Antibody Conjugates
EMD Millipore offers stem cell conjugates for some of the most popular stem cell markers in various formats including AlexaFluor-488, CY3, FITC and PE conjugated antibodies. “Flowselect” antibodies have been validated and are pre-diluted to work in flow cytometry applications. Other non “flowselect” antibody conjugates have been validated for Immunocytochemistry. All conjugates maintain their antigen specificities while eliminating the use of cumbersome secondary antibodies. Rely on the conjugated forms of these antibodies to collapse the experimental workflow and save time and money.
Characterization Kits
Due to our vast stem cell antibody product offering, we have developed many characterization kits for commonly differentiated stem cell derivatives. These kits contain a collection of commonly assayed monoclonal and polyclonal antibodies which are routinely used to identify the cell type of interest. These kits are a reliable solution used to quantify the level of differentiation achieved in different types of stem cells. Characterization kits are available for pluripotent stem cells, cardiomyocytes, pancreatic cells, neural stem cells, mesenchymal stem cells and many other cell types.
