Millipore Applications Bibliography |
 | Click on PDF above for full document. | |
Current Therapeutic Antibody Production and Process Optimization | ||
| Authors: | FENG LI, JOE X. ZHOU, XIAOMING YANG, TIM TRESSEL, and BRIAN LEE | |
| Citation: | BioProcessing Journal, September/October 2005; RP1017EN00 | |
| Year: | 2005 | |
| Two major areas of commercial antibody process development are described in this review article: upstream cell culture and downstream purification processes. Upstream process development includes cell line development, media optimization, and cell culture process optimization. Downstream process development comprises cell harvest, antibody capture, viral inactivation, and polishing steps. This article provides an updated review and discussion of the technologies used in recent therapeutic antibody production processes. | ||
Please note: This information is provided to you for technical reference. A reprint of the document cited is available from the publisher or from your local library and is not available from Millipore. For further assistance, please contact Millipore's Technical Services.