Millipore Technical Publications |
 | TN- AN1242EN00 | |
ReNcell Human Neural Progenitors: | ||
| Lit No: | AN1242EN00 | |
| Year: | 2008 | |
| Abstract ReNcell VM and ReNcell CX are two well-established neural stem cell lines derived from developing human brains. ReNcell VM and CX cells are generated from the ventral mesencephalon and cortical regions of the brain, respectively, and transduced with the myc transcription factor. Both cell lines offer phenotype and genotype stability, in addition to the multipotential neuronal differentiation capacity, over long-term culture. This article describes the characteristics and differentiation of ReNcell lines. Results of calcium and membrane potential changes in response to various ligands are also shown. The convenience to maintain in culture and flexibility to differentiate to individual scientists’ needs make ReNcell lines the ideal platform for research and discovery. Introduction Neural stem cells (NSCs) were first described in the rodent brain by Reynolds and Weis in 19921. Seven years later, the isolation of human NSCs was documented by Vescovi et al.2. Since those initial findings, NSCs have been valuable tools for neuroscience, signal transduction and developmental biology, to name but a few. Click the PDF above for the full document. | |
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