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Millipore Technical Publications


AN5226EN00_EM.pdfAN5226EN00_EM.pdf
AN- AN5226EN00

Assessing Enriched Murine CD4+ T Cells Differentiated Towards Effector T Helper Cell Lineages with the Scepter™ 2.0 Handheld Automated Cell Counter

Lit No:AN5226EN00
Year:2012



Introduction

Cellular differentiation is a fundamental process in developmental biology. Progenitor cells must have the ability to differentiate into more specialized cell types for the body to respond to infections, eliciting an immune response. Murine CD4+ T cells can give rise to a variety of effector T, or “T helper”, cell subsets depending on the nature of the immune response, and subsequently release a distinct subset of cytokines. During T cell differentiation, a group of T helper (Th) cell subsets play a critical role in both the innate and adaptive immune response repertoire, defending the body against foreign pathogens.

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