Millipore Technical Publications |
 | DS- DS1031EN00 | |
UCOE Expression TechnologyMaximizes protein expression in mammalian cells | ||
| Lit No: | DS1031EN00 | |
| Year: | 2010 | |
| UCOE (Ubiquitous Chromatin Opening Element) expression
technology gives major improvements in gene expression
in stably-transfected mammalian cells through effects on
the structure of chromatin. UCOE expression technology
prevents transgene silencing and gives consistent,
stable and high-level gene expression irrespective of the
chromosomal integration site. UCOE expression elements
are small DNA elements (isolated from the area around
house-keeping genes, which need to be active most of the
time) that create a transcriptionally active, open chromatin
environment around an integrated transgene, maximizing its
potential to be transcribed into protein, irrespec
tive of the position of the transgene in the chromosome.
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