Millipore Technical Publications |
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CellCiphr Kit for Human HepatotoxicityThe Most Comprehensive Cell-Based Cytotoxicity Assay Available |
| In the high-stakes business of drug development, it is
critical to know everything you can about your lead
compounds as early as possible. Yet, liver damage, or
hepatotoxicity, continues to be a major factor in the high
failure rate of lead compounds, resulting in the withdrawal
of drugs from the market. The financial impact of losing a
lead drug candidate in the late stages can cost millions of
dollars. Therefore, reliable biomarkers of liver damage are
critical for accurate prediction of these potential causes of
drug failure. Responding to this need, Millipore has developed the CellCiphr kit for human hepatotoxicity. The most comprehensive cell-based cytotoxicity assay available, the panel represents a new way of prioritizing lead compounds based on multiple cytotoxicity indices. Using High Content Analysis (HCA) or automated fluorescence microscopy, you’re able to efficiently evaluate multiple cellular parameters in a single assay, screening compounds for a broad range of potentially toxic effects early in the drug discovery process. Click the PDF above for the full document. | |
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