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Millipore Technical Publications

DS1894EN00.pdf
DS- DS1894EN00

ChromaSorb Membrane Adsorber

A single-use, membrane-based anion exchanger offering the greatest levels of impurity binding at the highest salt concentrations for MAb and protein purification
Lit No:DS1894EN00
Year:2010

ChromaSorb membrane adsorber is an innovative, single-use, flow-through anion exchanger designed for the removal of trace impurities including host cell protein (HCP), DNA, endotoxins and viruses from monoclonal antibody or other protein feedstocks. Unlike traditional anionic resins and membranes, ChromaSorb membrane adsorber provides robust impurity removal over a wider conductivity range. The ability to consistently and reliably perform at greater salt concentrations significantly reduces buffer volumes typically used at this step. This single-use device significantly reduces validation requirements, capital equipment expenditures, time and labor when compared to traditional column based anion exchange resins.

ChromaSorb Membrane Adsorber Features
  • Robust strength of binding at high salt concentrations for improved process economics
  • Single-use device provides enhanced process flexibility and efficiency
  • Smaller manufacturing footprint than traditional anion resins and columns
  • Small-scale device designed to minimize use of feedstock during scaling studies
  • Linearly scalable family of devices
  • Easy to use at all sizes

Learn more...

Click the PDF above for the full document.