Millipore Technical Publications |
 | DS- PF3389EN00 | |
UbiquitinProfiler™ ServicesSimplifying Ubiquitination Drug Discovery | ||
| Lit No: | PF3389EN00 | |
| Year: | 2011 | |
| Ubiquitination is a fundamental and disease relevant cellular process Ubiquitin protein modification is an important regulatory mechanism for controlling cellular signaling and homeostasis. Research leading to the discovery of the role for the ubiquitination pathway in protein degradation was rewarded with a Nobel Prize in 2004. Since this pioneering work, ubiquitination has been identified to regulate a broad range of fundamental cellular processes, including cell cycle, DNA repair, apoptosis and receptor signaling. Importantly, deregulation of the pathway is linked with a number of human diseases, including inherited disorders (e.g., Angelman Syndrome) as well as acquired disorders like cancer, inflammatory disease, muscle-wasting disorders, and neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Click the PDF above for the full document. | |
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