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Millipore Technical Publications

PO- PS1020EN00

The Use of Size Exclusion Composite Membrane to Remove TSE Infectious Particles from a Model Protein Solution Filtration

Lit No:PS1020EN00

Filtration technology designed to remove conventional virus particles1 was tested for removal of PrPSc and TSE infectivity from a model protein solution. Western blot assay and animal bioassay demonstrated at least a 4.0 log reduction of PrPSc and infectivity after filtration. Partitioning of PrPSc was not affected by protein concentration or in the presence of detergents while processed in a tangential or a normal flow mode. These data indicate size exclusion filtration of biological products has the potential to significantly reduce the risk of TSE transmission.

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