Millipore Technical Publications |
 | PO- PS2486EN00 | |
Novel Assays to Harness the Drug Discovery Potential of Ubiquitination Pathways | ||
| Lit No: | PS2486EN00 | |
| Year: | 2011 | |
| Ubiquitination is a key regulatory mechanism which attaches the small
protein modifier ubiquitin to protein substrates, thereby modifying their
structure, function, cellular location, or targeting them for destruction via
proteolysis. Inappropriate regulation of ubiquitination pathways is linked
with a number of human diseases and in recent years, components of
these pathways have emerged as a new and relatively untapped class of
targets for drug discovery. Despite a clear opportunity for the
development of new therapeutic agents, exploration in this area has
been significantly hindered by the complexity of the systems involved
and the lack of suitable technology to allow identification of compounds
with therapeutic potential. Here, we describe the development of robust
assays for a number of ubiquitination pathway enzymes which can be
used to screen compounds and assess their selectivity. Click the PDF above for the full document. | |
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