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Millipore Technical Publications

PS3245EN00.pdf
PO- PS3245EN00

Optimizing a Luminescent Calcium Biosensor for Screening GPCRs on Multiple Detection Platforms

Lit No:PS3245EN00
Year:2010


Millipore’s ChemiBrite GPCR technology allows luminescent detection of calcium flux triggered by GPCR activation.

Advantages of Luminescent Cellular Calcium Assays
  • Large calcium detection range (10-7 to 10-4M)
  • Low luminescent background
  • Substrate has little cellular toxicity and not subject to efflux
  • Compound auto-fluorescence is eliminated
  • Photoproteins can be targeted to different cellular compartments

Click the PDF above for the full document.