Millipore Technical Publications |
 | PO- PS4441EN00 | |
A broad activity screen in support of a chemogenomic map for kinase signaling research and drug discovery | ||
| Lit No: | PS4441EN00 | |
| Year: | 2012 | |
AbstractDespite the development of a number of efficacious kinase inhibitors, the strategies for rational design of these compounds have been limited by target promiscuity. In an effort to better understand the nature of structure and activity across the kinome, especially as it relates to off-target effects, we screened a well-defined collection of kinase inhibitors using “gold standard” radiometric assays for inhibitory activity toward 234 human kinases, representing all branches of the kinome tree except lipid kinases.Click the PDF above for the full document. | |
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