Millipore Technical Publications |
 | Tech Note | |
PAB – An Enhanced Sanitization Option for ProSep Chromatography Media | ||
| Lit No: | TB0011EN00 | |
| Year: | 2008 | |
| Protein A chromatography media, including ProSep
and ProSep Ultra Plus media, require sanitization between
batches as well as prior to storage. While stable at low
pH, protein A has limited stability at high pH. Even the new
protein A variants with improved caustic stability may
exhibit a noticeable loss in capacity at the higher NaOH
concentrations and/or longer contact times that may be
required for effective sanitization.
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