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Millipore Technical Publications


tb1700en00.pdf

Mobius MIX500 Disposable Mixing System Characterization


Lit No.TB1700en00
Year:2008

The need for faster cycle times and higher levels of operational flexibility has accelerated the adoption of single-use processing solutions in the biopharmaceutical industry. In response, Millipore has recently introduced the Mobius MIX systems – a family of disposable mixing systems that include the MIX100 (100L maximum operating volume), the MIX200 (200L maximum operating volume), and the MIX500 (500L maximum operating volume). The Mobius disposable MIX systems include a carrier, a disposable Mobius process container with an integral magnetically-driven levitating impeller, a motor and an electronic drive unit.

One of the most common daily process tasks in the biopharmaceutical industry is the mixing of media and buffer solutions for use in both upstream and downstream unit operations. The Mobius MIX systems have been successfully utilized for mixing a variety of media and buffer solutions. The following study provides characterization data for the performance of the Mobius MIX500 system at different impeller speeds, operating volumes, viscosities as well as operations in a cold room environment. In addition, the information presented in this technical brief can be used as a reference for numerous mixing applications.

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